abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is considered as one of the most aggressive cancers lacking efficient early detection biomarkers. Circulating miRNAs are now being considered to have potency to be used as diagnostic and prognostic biomarkers in different diseases as well as cancers. In case of cancer,...

journal_title：BMC cancer

authors： Chhatriya B,Mukherjee M,Ray S,Sarkar P,Chatterjee S,Nath D,Das K,Goswami S

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:Some historic breakthroughs have been made in immunotherapy of advanced cancer. However, there is still little research on immunotherapy in prostate cancer. We explored the relationship between immune cell infiltration and prostate cancer recurrence and tried to provide new ideas for the treatment of prostat...

journal_title：BMC cancer

authors： Rui X,Shao S,Wang L,Leng J

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:Deciphering the meaning of the human DNA is an outstanding goal which would revolutionize medicine and our way for treating diseases. In recent years, non-coding RNAs have attracted much attention and shown to be functional in part. Yet the importance of these RNAs especially for higher biological functions ...

journal_title：BMC cancer

authors： Smolander J,Stupnikov A,Glazko G,Dehmer M,Emmert-Streib F

更新日期：2019-12-03 00:00:00

abstract：:Following publication of the original article [1], the authors reported the following error is the article. ...

journal_title：BMC cancer

authors： Ye S,Hao X,Zhou T,Wu M,Wei J,Wang Y,Zhou L,Jiang X,Ji L,Chen Y,You L,Zhang Y,Xu G,Zhou J,Ma D,Wang S

更新日期：2019-11-29 00:00:00

abstract：BACKGROUND:Myeloid sarcoma (MS), also known as chloroma, is an extramedullary manifestation of malignant primitive myeloid cells. Previously, only small studies investigated clinical and imaging features of MS. The purpose of this study was to elucidate clinical and imaging features of MS based upon a multicenter patie...

journal_title：BMC cancer

authors： Meyer HJ,Pönisch W,Schmidt SA,Wienbeck S,Braulke F,Schramm D,Surov A

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:The platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and neutrophil to lymphocyte ratio (NLR) reflect the systematic inflammatory response, with some evidence revealing that they are associated with poorer survival in patients with gastric cancer. However, the effect of the white blood...

journal_title：BMC cancer

authors： Zheng HL,Lu J,Xie JW,Wang JB,Lin JX,Chen QY,Cao LL,Lin M,Tu RH,Huang ZN,Lin JL,Li P,Zheng CH,Huang CM

更新日期：2019-11-21 00:00:00

abstract：BACKGROUND:To investigate whether MRI findings, including texture analysis, can differentiate KRAS mutation status in rectal cancer. METHODS:Totally, 158 patients with pathologically proved rectal cancers and preoperative pelvic MRI examinations were enrolled. Patients were stratified into two groups: KRAS wild-type g...

journal_title：BMC cancer

authors： Xu Y,Xu Q,Ma Y,Duan J,Zhang H,Liu T,Li L,Sun H,Shi K,Xie S,Wang W

更新日期：2019-11-14 00:00:00

abstract：BACKGROUND:Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS) not only can promote cancer progression, but also they have recently emerged as mediators of the mucosal immune system. However, the roles and clinical relevance of the collective or individual NADPH oxidase (NO...

journal_title：BMC cancer

authors： Cho SY,Kim S,Son MJ,Kim G,Singh P,Kim HN,Choi HG,Yoo HJ,Ko YB,Lee BS,Eun HS

更新日期：2019-11-09 00:00:00

abstract：BACKGROUND:In past decades, circular RNAs (circRNAs) have achieved increasing attention because of its regulatory role in different kinds of cancers. However, how circAGFG1 regulates cervical cancer (CC) is still largely undiscovered. This study aims to evaluate the role of a novel circRNAs and related molecular mechan...

journal_title：BMC cancer

authors： Wu F,Zhou J

更新日期：2019-11-08 00:00:00

abstract：BACKGROUND:There has been a sharp rise in the incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) in many countries. Patients with HPV-positive OPSCC have a more favorable prognosis compared with HPV-negative OPSCC, leading to investigation and adoption of de-escalation trea...

journal_title：BMC cancer

authors： Nopmaneepaisarn T,Tangjaturonrasme N,Rawangban W,Vinayanuwattikun C,Keelawat S,Bychkov A

更新日期：2019-11-06 00:00:00

abstract：BACKGROUND:The receptor tyrosine kinases (RTKs) play critical roles in the development of cancers. Clear cell renal cell carcinoma (ccRCC) accounts for 75% of the RCC. The previous studies on the RTKs in ccRCCs mainly focused on their gene expressions. The activation and function of the RTKs in ccRCC have not been full...

journal_title：BMC cancer

authors： Zhang Q,Liu JH,Liu JL,Qi CT,Yan L,Chen Y,Yu Q

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:SMAD4 is frequently inactivated and associated with a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Abnormal SMAD4 expression also plays an important role in the malignant progression of PDAC. METHODS:We investigated SMAD4 status in PDAC by immunohistochemical methods to explore the relationshi...

journal_title：BMC cancer

authors： Wang Z,Li Y,Zhan S,Zhang L,Zhang S,Tang Q,Li M,Tan Z,Liu S,Xing X

更新日期：2019-11-04 00:00:00

abstract：BACKGROUND:Nicotinamide phosphoribosyltransferase (NAMPT) enzyme acts as the major enzyme in the nicotinamide adenine dinucleotide (NAD) synthesis salvage pathway. Deregulation of NAD could be associated with progression of several cancers such as breast cancer. Here, the consequence of NAMPT inhibition by miR-154 was ...

journal_title：BMC cancer

authors： Bolandghamat Pour Z,Nourbakhsh M,Mousavizadeh K,Madjd Z,Ghorbanhosseini SS,Abdolvahabi Z,Hesari Z,Ezzati Mobasser S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Budding is a complementary prognostic factor for colorectal cancer. In this study, we aimed to clarify the role of tumor budding in rectal cancer patients after preoperative chemoradiotherapy. METHODS:A total of 124 patients with rectal cancer treated with neoadjuvant chemoradiotherapy and consecutive surge...

journal_title：BMC cancer

authors： Trotsyuk I,Sparschuh H,Müller AJ,Neumann K,Kruschewski M,Horst D,Elezkurtaj S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Women with ovarian cancer can present with a variety of symptoms and signs, and an increasing range of tests are available for their investigation. A number of international guidelines provide advice for the initial assessment of possible ovarian cancer in symptomatic women. We systematically identified and ...

journal_title：BMC cancer

authors： Funston G,Van Melle M,Baun ML,Jensen H,Helsper C,Emery J,Crosbie EJ,Thompson M,Hamilton W,Walter FM

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Genetics-based basket trials have emerged to test targeted therapeutics across multiple cancer types. However, while vemurafenib is FDA-approved for BRAF-V600E melanomas, the non-melanoma basket trial was unsuccessful, suggesting mutation status is insufficient to predict response. We hypothesized that prote...

journal_title：BMC cancer

authors： Carroll MJ,Parent CR,Page D,Kreeger PK

更新日期：2019-10-31 00:00:00

abstract：BACKGROUND:Cancer cells release exosomes and can be taken up by mast cells (MCs), but the potential functional effects of MCs on tumor metastasis remain unknown. METHOD:Exosomes were isolated from the lung adenocarcinoma cell line A549, and the uptake of PKH26-labeled exosomes by bone marrow MCs was examined via flow ...

journal_title：BMC cancer

authors： Xiao H,He M,Xie G,Liu Y,Zhao Y,Ye X,Li X,Zhang M

更新日期：2019-10-29 00:00:00

abstract：BACKGROUND:We examined 15 years of key performance indicators (KPIs) of the population-based mammography screening programme (PMSP) in Flanders, Belgium. METHODS:Individual screening data were linked to the national cancer registry to obtain oncological follow-up. We benchmarked crude KPI results against KPI-targets s...

journal_title：BMC cancer

authors： Goossens M,De Brabander I,De Grève J,Van Ongeval C,Martens P,Van Limbergen E,Kellen E

更新日期：2019-10-28 00:00:00

abstract：BACKGROUND:To compare the value of two dynamic contrast-enhanced Magnetic Resonance Images (DCE-MRI) reconstruction approaches, namely golden-angle radial sparse parallel (GRASP) and view-sharing with golden-angle radial profile (VS-GR) reconstruction, and evaluate their values in assessing response to neoadjuvant chem...

journal_title：BMC cancer

authors： Lu Y,Ma L,Qin J,Wang Z,Guo J,Zhao Y,Zhang H,Yan X,Liu H,Li H,Kamel IR,Qu J

更新日期：2019-10-24 00:00:00

abstract：BACKGROUND:To determine the safety and efficacy of transarterial chemoembolization (TACE) combined with radiofrequency ablation (hereafter, TACE-RFA) in treating Barcelona Clinic Liver Cancer (BCLC) Stage A or B (hereafter, BCLC A/B) hepatocellular carcinoma (HCC) patients, and to explore the range of tumor sizes suita...

journal_title：BMC cancer

authors： Ren Y,Cao Y,Ma H,Kan X,Zhou C,Liu J,Shi Q,Feng G,Xiong B,Zheng C

更新日期：2019-10-22 00:00:00

abstract：BACKGROUND:Patients with metastatic renal carcinoma frequently have pre-existing renal impairment and not infrequently develop worsening renal function as a complication of their treatment. The presence of pancreatic metastases in patients with metastatic renal carcinoma, often confers a more favourable prognosis and a...

journal_title：BMC cancer

authors： Purshouse K,Chamberlain S,Soares M,Tuthill M,Protheroe A,Mole DR

更新日期：2019-10-17 00:00:00

abstract：BACKGROUND:We analyzed the changes in permeability of endothelial cell layers after photon irradiation, with a focus on the metalloproteases ADAM10 and ADAM17, and on VE-cadherin, components crucial for the integrity of endothelial intercellular junctions, and their roles in the transmigration of cancer cells through e...

journal_title：BMC cancer

authors： Kouam PN,Rezniczek GA,Adamietz IA,Bühler H

更新日期：2019-10-16 00:00:00

abstract：BACKGROUND:HER3 mediates drug resistance against epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs), resulting in tumor relapse in lung cancers. Previously, we demonstrated that EGFR induces HER3 overexpression, which facilitates the formation of cancer stem-like tumorspheres. However, the cellul...

journal_title：BMC cancer

authors： Chang YF,Lim KH,Chiang YW,Sie ZL,Chang J,Ho AS,Cheng CC

更新日期：2019-10-16 00:00:00

abstract：BACKGROUND:Leukemia is a cancer of blood and bone marrow cells, causing about 300,000 deaths worldwide. Photodynamic therapy (PDT) is a promising alternative for the treatment of malignant tumors. KillerRed is a genetically encoded red fluorescent protein photosensitizer (PS). In this study, we aimed to investigate the...

journal_title：BMC cancer

authors： Yuan M,Liu C,Li J,Ma W,Yu X,Zhang P,Ji Y

更新日期：2019-10-07 00:00:00

abstract：BACKGROUND:To investigate the implications of prophylactic intraoperative Hyperthermic Intraperitoneal Chemotherapy (HIPEC) with D2 radical gastrectomy for locally advanced Gastric Cancer (AGC) in a randomized case control study. METHOD:Eighty consecutive patients with locally AGC were randomly separated into 2 groups...

journal_title：BMC cancer

authors： Beeharry MK,Zhu ZL,Liu WT,Yao XX,Yan M,Zhu ZG

更新日期：2019-09-18 00:00:00

abstract：BACKGROUND:Free flap-mediated gene therapy in the tumor bed following surgical resection is a promising approach in cancer targeted treatment of residual disease. We investigated the selective killing efficacy of a lentivirus-mediated cytosine deaminase-thymidine kinase (CDglyTK) gene in transplanted breast cancer deli...

journal_title：BMC cancer

authors： Zhang J,Liu Y,Zang M,Zhu S,Chen B,Li S,Xue B,Yan L

更新日期：2019-09-14 00:00:00

abstract：:Following definitive chemoradiation for anal squamous cell carcinoma (ASCC), patients face a variety of chronic issues including: bowel dysfunction, accelerated bone loss, sexual dysfunction, and psychosocial distress. The increasing incidence of this disease, high cure rates, and significant long-term sequelae warran...

journal_title：BMC cancer

authors： Savoie MB,Laffan A,Brickman C,Daniels B,Levin A,Rowen T,Smith J,Van Blarigan EL,Hope TA,Berry-Lawhorn JM,Anwar M,Van Loon K

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:Appropriate assessment is essential for the management of chemotherapy-induced peripheral neuropathy (CIPN), an intractable symptom that cannot yet be palliated, which is high on the list of causes of distress for cancer patients. However, objective assessment by medical staff makes it easy to underestimate ...

journal_title：BMC cancer

authors： Kanda K,Fujimoto K,Mochizuki R,Ishida K,Lee B

更新日期：2019-09-10 00:00:00

abstract：BACKGROUND:Pseudomyogenic hemangioendothelioma (PMHE) is a rare endothelial neoplasm that involves the bones in only 14% of all cases. The optimal treatment strategy has not been established. We herein report a case of primary PMHE in which denosumab treatment showed activity in both imaging studies and the clinical ou...

journal_title：BMC cancer

authors： Otani S,Nakayama R,Sekita T,Hirozane T,Asano N,Nishimoto K,Sasaki A,Okita H,Morioka H,Nakamura M,Matsumoto M

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Few studies compared cancer incidence among migrants both to their host countries and to their population of origin. We aimed to compare cancer incidence of ethnic Germans who migrated from the former Soviet Union to Germany (resettlers) to those living in Russia as well as to the German and the Russian gene...

journal_title：BMC cancer

authors： Jaehn P,Kaucher S,Pikalova LV,Mazeina S,Kajüter H,Becher H,Valkov M,Winkler V

更新日期：2019-09-02 00:00:00

abstract：:Following publication of the original article [1], the authors reported the family name of the second author was incorrectly published. ...

journal_title：BMC cancer

authors： Doma V,Kárpáti S,Rásó E,Barbai T,Tímár J

更新日期：2019-08-29 00:00:00

abstract：BACKGROUND:Helicobacter pylori (H. pylori) is thought to have an oncogenic effect on the development of gastric malignancies. However, the effect of H. pylori status on the prognosis of gastric diffuse large B-cell lymphoma (DLBCL) remains unconfirmed. This study aimed to identify the prognostic importance of H. pylori...

journal_title：BMC cancer

authors： Cheng Y,Xiao Y,Zhou R,Liao Y,Zhou J,Ma X

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:The concept of head and neck cancers (HNSCC) having unique molecular signatures is well accepted but relating this to clinical presentation and disease behaviour is essential for patient benefit. Currently the clinical significance of HNSCC molecular subtypes is uncertain therefore personalisation of HNSCC t...

journal_title：BMC cancer

authors： Qadir F,Lalli A,Dar HH,Hwang S,Aldehlawi H,Ma H,Dai H,Waseem A,Teh MT

更新日期：2019-08-23 00:00:00

abstract：BACKGROUND:Genomic initiatives such as The Cancer Genome Atlas (TCGA) contain data from -omics profiling of thousands of tumor samples, which may be used to decipher cancer signaling, and related alterations. Managing and analyzing data from large-scale projects, such as TCGA, is a demanding task. It is difficult to di...

journal_title：BMC cancer

authors： Lucchetta M,da Piedade I,Mounir M,Vabistsevits M,Terkelsen T,Papaleo E

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Natural killer (NK) cell dysfunction following cancer surgery has been shown to promote metastases. Recent studies demonstrate an emerging role for lipids in the modulation of NK cell innate responses. However, the mechanisms involved in lipid modulation of NK cell postoperative anti-tumor function are unkno...

journal_title：BMC cancer

authors： Niavarani SR,Lawson C,Bakos O,Boudaud M,Batenchuk C,Rouleau S,Tai LH

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment option for patients with oligometastatic disease. SABR delivers precise, high-dose, hypofractionated radiotherapy, and achieves excellent rates of local control for primary tumors or metastases. A recent randomized phase II trial evalua...

journal_title：BMC cancer

authors： Palma DA,Olson R,Harrow S,Correa RJM,Schneiders F,Haasbeek CJA,Rodrigues GB,Lock M,Yaremko BP,Bauman GS,Ahmad B,Schellenberg D,Liu M,Gaede S,Laba J,Mulroy L,Senthi S,Louie AV,Swaminath A,Chalmers A,Warner A,Slot

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:Diets that restrict energy or macronutrient intake (e.g. fasting/ketogenic diets (KDs)) may selectively protect non-tumour cells during cancer treatment. Previous reviews have focused on a subset of dietary restrictions (DR) or have not performed systematic searches. We conducted a systematic scoping review ...

journal_title：BMC cancer

authors： Shingler E,Perry R,Mitchell A,England C,Perks C,Herbert G,Ness A,Atkinson C

更新日期：2019-08-15 00:00:00

abstract：BACKGROUND:We report an extremely rare case of vaginal clear cell carcinoma, which originated from the malignant transformation of vaginal adenosis without prenatal diethylstilbestrol (DES) exposure. CASE PRESENTATION:In this case, the patient was a Chinese woman with a history of two decades of intermittent vaginal p...

journal_title：BMC cancer

authors： Pang L,Li L,Zhu L,Lang J,Bi Y

更新日期：2019-08-13 00:00:00

abstract：BACKGROUND:Increasing evidence revealed that high expression level of lncRNA SNHG1 was associated with the unfavorable prognosis of cancer and maybe used as a valuable biomarker for cancer patients. The present meta->analysis is to analyze existing data to reveal potential clinical application of SNHG1 on cancer progno...

journal_title：BMC cancer

authors： Dong B,Chen X,Zhang Y,Zhu C,Dong Q

更新日期：2019-08-07 00:00:00

abstract：BACKGROUND:Many patients diagnosed with oesophageal adenocarcinoma (OAC) present with advanced disease and approximately half present with metastatic disease. Patients with localised disease, who are managed with curative intent, frequently undergo neoadjuvant chemoradiotherapy. Unfortunately, ~ 70% of patients have li...

journal_title：BMC cancer

authors： Bibby BAS,Miranda CS,Reynolds JV,Cawthorne CJ,Maher SG

更新日期：2019-08-07 00:00:00